S1PR5 Gene Summary [Human]
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | S1PR5 |
| Official Name | sphingosine-1-phosphate receptor 5 [Source:HGNC Symbol;Acc:HGNC:14299] |
| Ensembl ID | ENSG00000180739 |
| Bio databases IDs | |
| Aliases | sphingosine-1-phosphate receptor 5 |
| Synonyms | EDG8, lpB4, S1P5, sphingosine-1-phosphate receptor 5, SPPR-1, SPPR-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S1PR5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the S1PR5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- depressive disorder
- ulcerative colitis
- Huntington disease
- multiple sclerosis
- relapsing multiple sclerosis
- relapsing-remitting multiple sclerosis
- non-insulin-dependent diabetes mellitus
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- demyelination
role in cell
- migration
- proliferation
- injury
- activation in
- response in
- differentiation
- binding
- quantity
- activation
- mobilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- presynaptic regions
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S1PR5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of metabolic process
- regulation of neuron differentiation
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- sphingosine-1-phosphate signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- sphingosine-1-phosphate receptor activity
- protein binding