GPR157 Gene Summary [Human]

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway and radial glial cell differentiation. Predicted to be located in ciliary membrane. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
GPR157
Official Name
G protein-coupled receptor 157 [Source:HGNC Symbol;Acc:HGNC:23687]
Ensembl ID
ENSG00000180758
Bio databases IDs NCBI: 80045 Ensembl: ENSG00000180758
Aliases G protein-coupled receptor 157
Synonyms F730108M23RIK, G protein-coupled receptor 157
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR157 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor

Pathways

Biological processes and signaling networks where the GPR157 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • lymphomagenesis
  • primary cancer
  • central nervous system cancer
  • idiopathic pulmonary fibrosis
  • primary central nervous system lymphoma
regulated by
role in cell
  • growth
  • differentiation
  • cisplatin sensitivity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cilia
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GPR157 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • radial glial cell differentiation
  • cell surface receptor signaling pathway
  • circadian behavior
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • phospholipase C-activating G-protein coupled receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • cilium membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • G-protein coupled receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.