METTL23 Gene Summary [Human]
The protein encoded by this gene functions as a transcription factor regulator in the transcriptional pathway for human cognition. It is a partner of the alpha subunit of the GA-binding protein transcription factor. Mutations in this gene cause mild autosomal recessive intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | METTL23 |
| Official Name | methyltransferase like 23 [Source:HGNC Symbol;Acc:HGNC:26988] |
| Ensembl ID | ENSG00000181038 |
| Bio databases IDs | |
| Aliases | methyltransferase like 23 |
| Synonyms | 1110005A03Rik, 1500035B17Rik, 4933424L15Rik, C17orf95, methyltransferase 23, arginine, methyltransferase like 23, MRT44, RGD1306284 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METTL23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- histone methyltransferase
- heat shock protein binding
- transcription factor binding
- protein binding
- AdoMet_MTases
- protein-arginine N-methyltransferase
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- pronucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METTL23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cognition
- peptidyl-lysine methylation
- positive regulation of transcription from RNA polymerase II promoter
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- male pronucleus
- cytoplasm
- macromolecular complex
- female pronucleus
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- heat shock protein binding
- protein binding
- histone methyltransferase activity (H3-R17 specific)
- protein-lysine N-methyltransferase activity