Mettl23 Gene Summary [Mouse]
Enables histone H3R17 methyltransferase activity. Involved in epigenetic programming in the zygotic pronuclei. Acts upstream of with a positive effect on epigenetic programing of male pronucleus. Located in cytoplasm and female pronucleus. Is active in male pronucleus. Is expressed in embryo. Used to study glaucoma. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 44. Orthologous to human METTL23 (methyltransferase 23, arginine). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mettl23 |
| Official Name | methyltransferase like 23 [Source:MGI Symbol;Acc:MGI:1921569] |
| Ensembl ID | ENSMUSG00000090266 |
| Bio databases IDs | |
| Aliases | methyltransferase like 23 |
| Synonyms | 1110005A03Rik, 1500035B17Rik, 4933424L15Rik, C17orf95, methyltransferase 23, arginine, methyltransferase like 23, MRT44, RGD1306284 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mettl23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- histone methyltransferase
- heat shock protein binding
- transcription factor binding
- protein binding
- AdoMet_MTases
- protein-arginine N-methyltransferase
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- pronucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mettl23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cognition
- peptidyl-lysine methylation
- positive regulation of transcription from RNA polymerase II promoter
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- male pronucleus
- cytoplasm
- macromolecular complex
- female pronucleus
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- heat shock protein binding
- protein binding
- histone methyltransferase activity (H3-R17 specific)
- protein-lysine N-methyltransferase activity