RAP2B Gene Summary [Human]
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | RAP2B |
| Official Name | RAP2B, member of RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9862] |
| Ensembl ID | ENSG00000181467 |
| Bio databases IDs | |
| Aliases | RAP2B, member of RAS oncogene family, Ras-related protein RAP-2B, small GTP binding protein, Ras family small GTP binding protein RAP2B |
| Synonyms | 4021402C18Rik, RAP2B, member of RAS oncogene family |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAP2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- protein domain specific binding
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RAP2B gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- Chemokine Signaling
- CNTF Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- Oncostatin M Signaling
- PAK Signaling
- PDGF Signaling
- PEDF Signaling
- PPAR Signaling
- Prolactin Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- TGF-β Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- adenomyosis
- peripheral arterial disease
- uterine leiomyoma
- leiomyomatosis
role in cell
- activation in
- migration
- activation
- accumulation in
- aggregation
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- intercellular junctions
- tertiary granule membrane
- specific granule membrane
- cytosol
- endosomal membrane
- recycling endosomes
- tight junctions
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAP2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein autophosphorylation
- signal transduction
- regulation of protein tyrosine kinase activity
- microvillus assembly
- Rap protein signal transduction
- platelet aggregation
- platelet activation
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cell-cell contact zone
- tight junction
- extracellular vesicular exosome
- membrane raft
- membrane
- cytosol
- recycling endosome membrane
- tertiary granule membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein domain specific binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding