ZBTB2 Gene Summary [Human]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB2 |
| Official Name | zinc finger and BTB domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20868] |
| Ensembl ID | ENSG00000181472 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 2 |
| Synonyms | Gm1103, zinc finger and BTB domain containing 2, ZNF437 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBTB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger double domain
- BTB_POZ
- BTB/POZ domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- advanced cancer
- infection by HIV-1
regulated by
- beta-estradiol
- progestin
- cantharidin
- BMP2
regulates
- RNA polymerase II
- HIF1A
- DNA promoter
- DNA endogenous promoter
role in cell
- invasion by
- transactivation in
- BAPTA-AM resistance
- replication in
- tanespimycin sensitivity
- ipatasertib sensitivity
- pladienolide B resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBTB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cytokine production
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription