RFX7 Gene Summary [Human]
RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]).[supplied by OMIM, Mar 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | RFX7 |
| Official Name | regulatory factor X7 [Source:HGNC Symbol;Acc:HGNC:25777] |
| Ensembl ID | ENSG00000181827 |
| Bio databases IDs | |
| Aliases | regulatory factor X7 |
| Synonyms | 2510005N23RIK, 9930116O05RIK, D130086K05Rik, MRD71, regulatory factor X7, regulatory factor X, 7, RFXDC2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RFX7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RFX DNA-binding domain
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- RFX5 N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- hereditary disorder
- autosomal dominant intellectual developmental disorder with behavioral abnormalities type 71
- chronic lymphocytic leukemia
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- function
- inhibition in
- metabolism in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RFX7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity