POLR3H Gene Summary [Human]
Enables DNA-directed 5'-3' RNA polymerase activity. Involved in transcription by RNA polymerase III. Located in centrosome and nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | POLR3H |
| Official Name | RNA polymerase III subunit H [Source:HGNC Symbol;Acc:HGNC:30349] |
| Ensembl ID | ENSG00000100413 |
| Bio databases IDs | |
| Aliases | RNA polymerase III subunit H |
| Synonyms | 5031409G22Rik, C25, MGC29654, polymerase (RNA) III (DNA directed) polypeptide H, RNA polymerase III subunit H, RPC22.9, RPC8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR3H often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form
- DNA-directed RNA polymerase
- enzyme
- protein binding
- RNAP_Rpb7_N_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- optic atrophy type 9
- infantile cerebellar-retinal degeneration
- autosomal recessive optic atrophy
- optic atrophy
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase iii
- nucleic acid component or derivative
role in cell
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR3H gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription initiation from RNA polymerase III promoter
- innate immune response
- defense response to virus
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- intracellular membrane-bounded organelle
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- DNA-directed RNA polymerase activity