KCNIP1 Gene Summary [Human]
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Details
| Type | Processed Transcript |
| Official Symbol | KCNIP1 |
| Official Name | potassium voltage-gated channel interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:15521] |
| Ensembl ID | ENSG00000182132 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel interacting protein 1 |
| Synonyms | KCHIP1, Kchip1.2, Kv channel-interacting protein 1, potassium voltage-gated channel interacting protein 1, VABP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- EF-hand, calcium binding motif
- EF-hand domain pair
- potassium channel regulator
- calcium ion binding
- EFh
- protein binding
- ion channel
- EF-hand domain
- binding protein
- EF hand
- ion channel binding
- Eps15 homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- multiple sclerosis
- Huntington disease
- diabetic nephropathy
- acute myeloid leukemia
- drug allergy
- primary sclerosing cholangitis
- idiopathic generalized epilepsy
- mechanical hypersensitivity
- tic disorder
role in cell
- expression in
- excitability
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cytoplasmic face of plasma membrane
- rough endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- voltage-gated potassium channel complex
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- ion channel binding
- potassium channel regulator activity
- potassium channel activity