Kcnip1 Gene Summary [Rat]
Enables calcium ion binding activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in positive regulation of action potential. Located in dendrite and neuronal cell body. Part of potassium channel complex. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnip1 |
| Official Name | potassium voltage-gated channel interacting protein 1 [Source:RGD Symbol;Acc:70886] |
| Ensembl ID | ENSRNOG00000005365 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel interacting protein 1 |
| Synonyms | KCHIP1, Kchip1.2, Kv channel-interacting protein 1, potassium voltage-gated channel interacting protein 1, VABP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- EF-hand, calcium binding motif
- EF-hand domain pair
- potassium channel regulator
- calcium ion binding
- EFh
- protein binding
- ion channel
- EF-hand domain
- binding protein
- EF hand
- ion channel binding
- Eps15 homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- multiple sclerosis
- Huntington disease
- diabetic nephropathy
- acute myeloid leukemia
- drug allergy
- primary sclerosing cholangitis
- idiopathic generalized epilepsy
- mechanical hypersensitivity
- tic disorder
role in cell
- expression in
- excitability
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cytoplasmic face of plasma membrane
- rough endoplasmatic reticulum
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- voltage-gated potassium channel complex
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- ion channel binding
- potassium channel regulator activity
- potassium channel activity