KCNIP2 Gene Summary [Human]
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KCNIP2 |
| Official Name | potassium voltage-gated channel interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:15522] |
| Ensembl ID | ENSG00000120049 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel interacting protein 2 |
| Synonyms | AI851528, KCHIP2, Kv channel-interacting protein 2, LOC100911951, potassium voltage-gated channel interacting protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- palmitoylation site
- EF-hand domain pair
- potassium channel regulator
- calcium ion binding
- EFh
- protein binding
- identical protein binding
- EF-hand domain
- binding protein
- EF hand
- ion channel binding
- A-type (transient outward) potassium channel
- Eps15 homology domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- Huntington disease
- arrhythmia
- systemic lupus erythematosus
role in cell
- expression in
- function
- excitability
- repolarization
- action potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intracellular space
- Nucleus
- rough endoplasmatic reticulum
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane repolarization involved in regulation of cardiac muscle cell action potential
- potassium ion transport
- detection of calcium ion
- clustering of voltage-gated potassium channels
- signal transduction
- muscle contraction
- regulation of heart contraction
- synaptic transmission
- regulation of action potential
- membrane repolarization
Cellular Component
Where in the cell the gene product is active
- dendrite
- potassium channel complex
- cytoplasm
- voltage-gated potassium channel complex
- synapse
- Kv4.2-KChIP2 channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- A-type (transient outward) potassium channel activity
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
- ER retention sequence binding
- potassium channel regulator activity
- ion channel binding