NGRN Gene Summary [Human]
Enables rRNA binding activity. Involved in positive regulation of mitochondrial translation. Located in several cellular components, including intercellular bridge; mitotic spindle; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | NGRN |
| Official Name | neugrin, neurite outgrowth associated [Source:HGNC Symbol;Acc:HGNC:18077] |
| Ensembl ID | ENSG00000182768 |
| Bio databases IDs | |
| Aliases | neugrin, neurite outgrowth associated |
| Synonyms | AW552001, DSC92, LOC400446, Neugrin, neugrin, neurite outgrowth associated |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NGRN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- rRNA binding
- Neugrin
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytoplasmic bridges
- mitochondrial membrane
- mitochondrial matrix
- nucleoplasm
- nuclear bodies
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NGRN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- positive regulation of mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- mitochondrial membrane
- nuclear body
- mitotic spindle
- mitochondrion
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- rRNA binding