SPSB4 Gene Summary [Human]
Enables ubiquitin ligase-substrate adaptor activity. Involved in cellular protein metabolic process; positive regulation of protein polyubiquitination; and regulation of circadian rhythm. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPSB4 |
| Official Name | splA/ryanodine receptor domain and SOCS box containing 4 [Source:HGNC Symbol;Acc:HGNC:30630] |
| Ensembl ID | ENSG00000175093 |
| Bio databases IDs | |
| Aliases | splA/ryanodine receptor domain and SOCS box containing 4 |
| Synonyms | D030068E18Rik, RGD1562307, splA/ryanodine receptor domain and SOCS box containing 4, SSB-4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPSB4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- SPRY domain
- protein binding activity, bridging
- SOCS
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPSB4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- rhythmic process
- regulation of circadian rhythm
- intracellular signal transduction
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding