MALAT1 Gene Summary [Human]
This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | MALAT1 |
| Official Name | metastasis associated lung adenocarcinoma transcript 1 [Source:HGNC Symbol;Acc:HGNC:29665] |
| Ensembl ID | ENSG00000251562 |
| Bio databases IDs | |
| Aliases | metastasis associated lung adenocarcinoma transcript 1, metastasis associated in lung adenocarcinoma transcript 1, non-protein coding RNA 47, hepcarcin, nuclear enriched abundant transcript 2, nuclear paraspeckle assembly transcript 2 (non-protein coding), long intergenic non-protein coding RNA 47 |
| Synonyms | 2210401K01RIK, 9430072K23RIK, AI647968, HCN, HSALNG0084905, LINC00047, metastasis associated lung adenocarcinoma transcript 1, metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA), NCRNA00047, NEAT2, NONHSAG008675, PRO1073, PRO2853 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MALAT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding activity, bridging
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- non-small cell lung cancer
- lung squamous cell carcinoma
- non-small cell lung carcinoma
- squamous cell lung cancer
- breast adenocarcinoma
- large cell lung carcinoma
role in cell
- expression in
- proliferation
- phosphorylation in
- migration
- apoptosis
- cell viability
- quantity
- cell death
- binding in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear bodies
- nuclear speckles
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MALAT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of miRNA catabolic process
- cellular response to hypoxia
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- nucleus