TCEAL7 Gene Summary [Human]
Predicted to enable WW domain binding activity. Involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TCEAL7 |
| Official Name | transcription elongation factor A like 7 [Source:HGNC Symbol;Acc:HGNC:28336] |
| Ensembl ID | ENSG00000182916 |
| Bio databases IDs | |
| Aliases | transcription elongation factor A like 7 |
| Synonyms | 1110018P05Rik, transcription elongation factor A like 7, transcription elongation factor A (SII)-like 7, WEX5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCEAL7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Brain expressed X-linked like family
- transcription regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- urothelial bladder carcinoma
- transitional cell bladder cancer
- epithelial cancer
- lung squamous cell carcinoma
regulates
- NFkB (complex)
- BCL2L1
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCEAL7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- negative regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm