NEK2 Gene Summary [Human]
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | NEK2 |
| Official Name | NIMA related kinase 2 [Source:HGNC Symbol;Acc:HGNC:7745] |
| Ensembl ID | ENSG00000117650 |
| Bio databases IDs | |
| Aliases | NIMA related kinase 2, HsPK 21, protein phosphatase 1, regulatory subunit 111 |
| Synonyms | C77054, HsPK21, NIMA (never in mitosis gene a)-related expressed kinase 2, NIMA-related kinase 2, NLK1, PPP1R111, RP67 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- regulatory domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- leucine zipper domain
- PP1 binding domain
- coiled-coil domain
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- non-catalytic domain
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- breast carcinoma
- breast cancer
- epithelial cancer
- epithelial neoplasia
- asthma
- cutaneous melanoma
- cutaneous melanoma cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- growth
- proliferation
- apoptosis
- cell death
- phosphorylation in
- number
- degradation in
- activation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cilia
- Nucleus
- Plasma Membrane
- basal bodies
- centrosome
- centriole
- microtubules
- midbody
- cytoplasmic bridges
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- spindle pole
- kinetochores
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitosis
- chromosome segregation
- protein autophosphorylation
- protein phosphorylation
- regulation of mitotic centrosome separation
- mitotic cell cycle
- cell division
- positive regulation of telomerase activity
- spindle assembly
- centrosome separation
- meiotic cell cycle
- blastocyst development
- positive regulation of telomere maintenance via telomerase
- regulation of attachment of spindle microtubules to kinetochore
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- spindle pole
- kinetochore
- nucleolus
- condensed nuclear chromosome
- nucleoplasm
- microtubule
- nucleus
- centrosome
- cytoplasm
- cytosol
- macromolecular complex
- midbody
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein phosphatase binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity