AIFM3 Gene Summary [Human]
Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; flavin adenine dinucleotide binding activity; and metal ion binding activity. Involved in execution phase of apoptosis. Located in cytosol; endoplasmic reticulum; and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AIFM3 |
| Official Name | apoptosis inducing factor mitochondria associated 3 [Source:HGNC Symbol;Acc:HGNC:26398] |
| Ensembl ID | ENSG00000183773 |
| Bio databases IDs | |
| Aliases | apoptosis inducing factor mitochondria associated 3 |
| Synonyms | 2810401C16Rik, AI840249, AIF family member 3, AIFL, apoptosis-inducing factor, mitochondrion-associated 3, FLJ30473, RGD1306028 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AIFM3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Rieske
- Pyridine nucleotide-disulphide oxidoreductase
- enzyme
- Rieske [2Fe-2S] domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- mitochondrial fraction
- outer membranes
- inner membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AIFM3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- endoplasmic reticulum
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- flavin adenine dinucleotide binding
- oxidoreductase activity, acting on NADH or NADPH
- 2 iron, 2 sulfur cluster binding