RARG Gene Summary [Human]
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | RARG |
| Official Name | retinoic acid receptor gamma [Source:HGNC Symbol;Acc:HGNC:9866] |
| Ensembl ID | ENSG00000172819 |
| Bio databases IDs | |
| Aliases | retinoic acid receptor gamma |
| Synonyms | LOC683586, NR1B3, RARC, RARD, RARgamma, Rar γ, retinoic acid receptor gamma, retinoic acid receptor, gamma, retinoic acid receptor γ, retinoic acid receptor, γ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RARG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- A/B region
- transcription activation domain
- AF-2 transcription activation domain
- chromatin binding
- fxfp sequence
- hormone binding domain
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- AF-1 domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- a/b binding pocket
- activation domain
- dimerization domain
- DNA binding domain
- nuclear localization sequence
- protein binding
- sequence-specific DNA binding
- DNA binding
- double-stranded DNA binding
- retinoid X receptor binding
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the RARG gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- HIV infection
- Kaposi sarcoma
- schizophrenia
- acne vulgaris
- type M3 acute myeloid leukemia
- psoriasis
- nodular ganglioneuroblastoma
- renal cancer
role in cell
- binding in
- expression in
- apoptosis
- proliferation
- inhibition in
- phosphorylation in
- cellular infiltration by
- survival
- migration
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RARG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- prostate gland epithelium morphogenesis
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- regulation of cell size
- positive regulation of programmed cell death
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- growth plate cartilage chondrocyte growth
- face development
- glandular epithelial cell development
- hormone-mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- response to retinoic acid
- retinoic acid receptor signaling pathway
- neural tube closure
- embryonic eye morphogenesis
- Harderian gland development
- stem cell proliferation
- apoptotic process
- canonical Wnt receptor signaling pathway
- embryonic hindlimb morphogenesis
- embryonic camera-type eye development
- regulation of myeloid cell differentiation
- trachea cartilage development
- negative regulation of stem cell proliferation
- cellular response to retinoic acid
- positive regulation of gene expression
- positive regulation of apoptotic process
- cell differentiation
- regulation of myelination
- negative regulation of chondrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin binding
- retinoid X receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity