IQGAP3 Gene Summary [Human]
Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to act upstream of or within several processes, including intracellular signal transduction; positive regulation of macromolecule metabolic process; and positive regulation of mammary gland epithelial cell proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IQGAP3 |
| Official Name | IQ motif containing GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:20669] |
| Ensembl ID | ENSG00000183856 |
| Bio databases IDs | |
| Aliases | IQ motif containing GTPase activating protein 3 |
| Synonyms | AI593484, D030034H08, IQ motif containing GTPase activating protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IQGAP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- calmodulin binding
- RasGAP C-terminus
- enzyme binding
- protein binding
- IQ calmodulin-binding motif
- Ras GTPase Activating Domain
- myosin binding
- GTPase-activator protein for Ras-like GTPases
- Calmodulin-binding motif
- WW
- GTPase-activator protein for Ras-like GTPase
- calponin homology (CH) domain superfamily
Pathways
Biological processes and signaling networks where the IQGAP3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chromophobe renal cancer
- lymphomagenesis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- organismal death
- colorectal cancer
- MYC mutation positive B-cell lymphoma
- B cell cancer
- chromosomal instability
- idiopathic inflammatory myopathy
role in cell
- growth
- size
- camptothecin sensitivity
- cisplatin sensitivity
- doxorubicin sensitivity
- G1/S phase transition
- radiosensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intercellular junctions
- cytosol
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IQGAP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERK1 and ERK2 cascade
- negative regulation of gene expression
- positive regulation of gene expression
- G1/S transition of mitotic cell cycle
- regulation of cell size
- positive regulation of protein phosphorylation
- mammary gland epithelial cell proliferation
- gene expression
- Ras protein signal transduction
- positive regulation of MAPK cascade
- positive regulation of mammary gland epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- cell-cell junction
- cell cortex
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- calmodulin binding
- protein binding
- GTPase activator activity
- small GTPase binding
- myosin VI light chain binding