HCAR2 Gene Summary [Human]
Predicted to enable nicotinic acid receptor activity. Involved in neutrophil apoptotic process and positive regulation of neutrophil apoptotic process. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | HCAR2 |
| Official Name | hydroxycarboxylic acid receptor 2 [Source:HGNC Symbol;Acc:HGNC:24827] |
| Ensembl ID | ENSG00000182782 |
| Bio databases IDs | |
| Aliases | hydroxycarboxylic acid receptor 2, niacin receptor 1 |
| Synonyms | GPR109A, Gpr109b, HCA2, HM74, HM74A, HM74b, hydroxycarboxylic acid receptor 2, mHM74b, NIACR1, PUMA-G, rHM74b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HCAR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- GTP binding
- Cholecystokinin A receptor, N-terminal
- purinergic nucleotide receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the HCAR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- sinapinic acid
- nicotinic acid
- methyl hydrogen fumarate
- gallic acid
- 3-hydroxybutyric acid
- ferulic acid
- acetoacetic acid
- salicylic acid
- (E)-2-hydroxycinnamic acid
- acifran
disease
- diabetes mellitus
- neoplasia
- metabolic syndrome X
- schizophrenia
- mixed hyperlipidemia
- familial hyperlipoproteinemia type IIa
- hypercholesterolemia
- insulin resistance
- psychosis
- hyperlipidemia
role in cell
- expression in
- phosphorylation in
- apoptosis
- activation in
- cellular infiltration by
- number
- growth
- chemotaxis
- production in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HCAR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- positive regulation of adiponectin secretion
- positive regulation of neutrophil apoptotic process
- neutrophil apoptotic process
- negative regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nicotinic acid receptor activity