PPP2CB Gene Summary [Human]
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PPP2CB |
| Official Name | protein phosphatase 2 catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:9300] |
| Ensembl ID | ENSG00000104695 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2 catalytic subunit beta, protein phosphatase 2A catalytic subunit, beta isoform |
| Synonyms | D8Ertd766e, Pp2a2, PP2Abeta, PP2Ac, PP2Ac beta, PP2Ac β, PP2CB, protein phosphatase 2 catalytic subunit beta, protein phosphatase 2 catalytic subunit β, protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform, protein phosphatase 2 (formerly 2A), catalytic subunit, β isoform |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP2CB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- protein phosphatase
- phosphatase
- ion channel binding
- metallophosphatase superfamily, metallophosphatase domain
- Protein phosphatase 2A homologues, catalytic domain
- protein binding
- protein heterodimerization
- Calcineurin-like phosphoesterase
Pathways
Biological processes and signaling networks where the PPP2CB gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- osteogenesis imperfecta type III
role in cell
- phosphorylation in
- activation in
- signaling in
- morphology
- G2/M phase
- G2 phase
- CSN5i-3 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP2CB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- negative regulation of NF-kappaB transcription factor activity
- protein dephosphorylation
- response to antibiotic
- response to hydrogen peroxide
- mitotic cell cycle
- peptidyl-serine dephosphorylation
- negative regulation of gene expression
- proteasomal ubiquitin-dependent protein catabolic process
- apoptotic mitochondrial changes
- negative regulation of Ras protein signal transduction
- negative regulation of tumor necrosis factor-mediated signaling pathway
- response to lead ion
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle pole
- cytosol
- chromosome, centromeric region
- protein phosphatase type 2A complex
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- tau protein binding
- ion channel binding
- myosin phosphatase activity