PRKX Gene Summary [Human]
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | PRKX |
| Official Name | protein kinase X-linked [Source:HGNC Symbol;Acc:HGNC:9441] |
| Ensembl ID | ENSG00000183943 |
| Bio databases IDs | |
| Aliases | protein kinase X-linked |
| Synonyms | Pkare, PKX1, protein kinase cAMP-dependent X-linked catalytic subunit, protein kinase, X-linked, Putative serine/threonine kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- cAMP-dependent protein kinase
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Protein tyrosine and serine/threonine kinase
- alcohol group acceptor phosphotransferase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Turner syndrome
- Huntington disease
- Klinefelter syndrome
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- infection by HIV-1
role in cell
- differentiation
- proliferation
- phagocytosis
- migration
- adhesion
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube morphogenesis
- kidney morphogenesis
- protein autophosphorylation
- cell adhesion
- endothelial cell migration
- angiogenesis
- protein kinase A signaling cascade
- myeloid cell differentiation
- endothelial cell proliferation
- regulation of cell adhesion
- peptidyl-serine phosphorylation
- cell-substrate adhesion
- regulation of cell migration
- regulation of epithelial cell differentiation involved in kidney development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cAMP-dependent protein kinase activity