Prkx Gene Summary [Mouse]
Predicted to enable cAMP-dependent protein kinase activity. Involved in angiogenesis; cell adhesion; and endothelial cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; cardiovascular system; central nervous system; gonad; and gut. Orthologous to several human genes including PRKX (protein kinase cAMP-dependent X-linked catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkx |
| Official Name | protein kinase, X-linked [Source:MGI Symbol;Acc:MGI:1309999] |
| Ensembl ID | ENSMUSG00000035725 |
| Bio databases IDs | |
| Aliases | protein kinase, X-linked |
| Synonyms | Pkare, PKX1, protein kinase cAMP-dependent X-linked catalytic subunit, protein kinase, X-linked, Putative serine/threonine kinase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- cAMP-dependent protein kinase
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Protein tyrosine and serine/threonine kinase
- alcohol group acceptor phosphotransferase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Turner syndrome
- Huntington disease
- Klinefelter syndrome
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- infection by HIV-1
role in cell
- differentiation
- proliferation
- phagocytosis
- migration
- adhesion
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube morphogenesis
- kidney morphogenesis
- protein autophosphorylation
- cell adhesion
- endothelial cell migration
- angiogenesis
- protein kinase A signaling cascade
- myeloid cell differentiation
- endothelial cell proliferation
- regulation of cell adhesion
- peptidyl-serine phosphorylation
- cell-substrate adhesion
- regulation of cell migration
- regulation of epithelial cell differentiation involved in kidney development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cAMP-dependent protein kinase activity