Acot3 Gene Summary [Mouse]
Enables fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process and carboxylic acid metabolic process. Located in cytosol and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acot3 |
| Official Name | acyl-CoA thioesterase 3 [Source:MGI Symbol;Acc:MGI:2159619] |
| Ensembl ID | ENSMUSG00000021228 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 3 |
| Synonyms | ACH2, Acot3, acyl-CoA thioesterase 1, acyl-CoA thioesterase 3, AW108394, CTE-1, LACH2, Pte2a, PTE-Ia, RGD1564089 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acot3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyl-CoA hydrolase
- thiolester hydrolase
- alpha/beta hydrolases
- Acyl-CoA thioester hydrolase/BAAT N-terminal region
- enzyme
- protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- breast cancer
- squamous-cell carcinoma
- squamous cell cancer
- hepatocellular carcinoma
- cardiomyopathy
- renal clear cell adenocarcinoma
- renal clear cell cancer
- diabetic nephropathy
regulates
- acyl-coenzyme A
- long chain fatty acid
- very long chain fatty acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acot3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- long-chain fatty acid metabolic process
- very long-chain fatty acid metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- acyl-CoA hydrolase activity
- carboxylic ester hydrolase activity