CDK10 Gene Summary [Human]
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Details
| Type | Protein Coding |
| Official Symbol | CDK10 |
| Official Name | cyclin dependent kinase 10 [Source:HGNC Symbol;Acc:HGNC:1770] |
| Ensembl ID | ENSG00000185324 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 10 |
| Synonyms | ALSAS, cyclin-dependent kinase 10, PISSLRE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- cyclin-dependent protein kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- protein binding
- Protein kinase domain
Pathways
Biological processes and signaling networks where the CDK10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- global developmental delay
- Al Kaissi syndrome
- hypoplasia
- hereditary disorder
- growth failure
- melanoma
- melanoma cancer
- atelectasis
role in cell
- proliferation
- expression in
- growth
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- intracellular space
- basal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin cytoskeleton organization
- negative regulation of cell proliferation
- cell projection organization
- traversing start control point of mitotic cell cycle
- positive regulation of MAPK cascade
- protein phosphorylation
- regulation of mitotic cell cycle
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium basal body
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity