KRT73 Gene Summary [Human]
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Details
| Type | Protein Coding |
| Official Symbol | KRT73 |
| Official Name | keratin 73 [Source:HGNC Symbol;Acc:HGNC:28928] |
| Ensembl ID | ENSG00000186049 |
| Bio databases IDs | |
| Aliases | keratin 73 |
| Synonyms | CK-73, IRT6IRS3, K6IRS3, K73, Kb36, keratin 73, KRT6IRS3, LOC105369772 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KRT73 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ciliary protein causing Leber congenital amaurosis disease
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- protein binding
- Intermediate filament protein
- Keratin type II head
- Apolipoprotein A1/A4/E domain
- FlgN protein
Pathways
Biological processes and signaling networks where the KRT73 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KRT73 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinization
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- keratin filament
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding