UCHL5 Gene Summary [Human]
Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UCHL5 |
| Official Name | ubiquitin C-terminal hydrolase L5 [Source:HGNC Symbol;Acc:HGNC:19678] |
| Ensembl ID | ENSG00000116750 |
| Bio databases IDs | |
| Aliases | ubiquitin C-terminal hydrolase L5, INO80 complex subunit R |
| Synonyms | 5830413B11Rik, CGI-70, INO80R, ubiquitin carboxyl-terminal esterase L5, ubiquitin C-terminal hydrolase L5, UCH37 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UCHL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin carboxyl-terminal hydrolases
- endopeptidase inhibitor
- binding protein
- peptidase
- ubiquitin-specific protease
- protein binding
- cysteine peptidase C12
Pathways
Biological processes and signaling networks where the UCHL5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- cancer
- osteosarcoma
- osteosarcomagenesis
- diffuse large B-cell lymphoma
- breast cancer
- sarcoma
- cannabis dependence
- obesity
role in cell
- expression in
- apoptosis
- phosphorylation in
- degradation in
- activation in
- replication in
- cell cycle progression
- organization
- ubiquitination in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UCHL5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- positive regulation of DNA repair
- DNA repair
- regulation of proteasomal protein catabolic process
- regulation of chromosome organization
- regulation of DNA strand elongation
- regulation of DNA repair
- DNA recombination
- regulation of embryonic development
- telomere maintenance
- regulation of DNA replication
- forebrain morphogenesis
- ubiquitin-dependent protein catabolic process
- chromatin remodeling
- midbrain development
- lateral ventricle development
- positive regulation of transcription, DNA-dependent
- positive regulation of smoothened signaling pathway
- regulation of cell cycle
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- cytosolic proteasome complex
- Ino80 complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- RNA binding
- protein binding
- endopeptidase inhibitor activity
- proteasome binding