UBASH3B Gene Summary [Human]
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | UBASH3B |
| Official Name | ubiquitin associated and SH3 domain containing B [Source:HGNC Symbol;Acc:HGNC:29884] |
| Ensembl ID | ENSG00000154127 |
| Bio databases IDs | |
| Aliases | ubiquitin associated and SH3 domain containing B, SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate, T-cell ubiquitin ligand 2 |
| Synonyms | 2810457I06Rik, KIAA1959, p70, RGD1310357, STS-1, TULA-2, ubiquitin associated and SH3 domain containing B, ubiquitin associated and SH3 domain containing, B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBASH3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- protein-tyrosine-phoshatase
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- phosphoprotein binding
- enzyme
- Histidine phosphatase domain
- protein binding
- alpha-ribazole phosphatase
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the UBASH3B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cardiovascular disorder
- experimental autoimmune encephalomyelitis
- systemic lupus erythematosus
- preeclampsia
- cerebral atherosclerosis
role in cell
- differentiation
- phosphorylation in
- activation in
- tyrosine phosphorylation in
- proliferation
- number
- signaling in
- autophagy by
- aggregation
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBASH3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of release of sequestered calcium ion into cytosol
- negative regulation of signal transduction
- regulation of osteoclast differentiation
- negative regulation of platelet aggregation
- negative regulation of osteoclast differentiation
- collagen-activated tyrosine kinase receptor signaling pathway
- negative regulation of bone resorption
- platelet aggregation
- negative regulation of protein kinase activity
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- protein tyrosine phosphatase activity
- phosphoprotein binding