KDM4D Gene Summary [Human]
Enables histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K9 demethylation. Acts upstream of or within several processes, including cellular response to ionizing radiation; positive regulation of chromatin binding activity; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KDM4D |
| Official Name | lysine demethylase 4D [Source:HGNC Symbol;Acc:HGNC:25498] |
| Ensembl ID | ENSG00000186280 |
| Bio databases IDs | |
| Aliases | lysine demethylase 4D |
| Synonyms | 4932416A15, JMJD2D, LOC684198, lysine demethylase 4D, lysine (K)-specific demethylase 4D |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KDM4D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- jmjN domain
- damaged DNA binding
- 2-oxoglutarate:oxygen oxidoreductase
- chromatin binding
- enzyme
- protein binding
- histone demethylase activity
- RmlC-like cupin superfamily
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- diabetic nephropathy
- colorectal carcinoma
- colorectal carcinomagenesis
- Crohn disease
- colorectal cancer
- dextran sodium sulfate-induced colitis
- ulcerative colitis
- infection by HIV-1
role in cell
- proliferation
- apoptosis
- expression in
- migration
- binding
- invasion by
- response by
- abnormal morphology
- formation by
- demethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KDM4D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- chromatin remodeling
- positive regulation of chromatin binding
- regulation of protein phosphorylation
- regulation of gene expression
- double-strand break repair via homologous recombination
- cellular response to ionizing radiation
- positive regulation of double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- blood microparticle
- chromatin
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- metal ion binding
- histone demethylase activity (H3-K9 specific)
- histone demethylase activity
- damaged DNA binding