THBS2 Gene Summary [Human]
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | THBS2 |
| Official Name | thrombospondin 2 [Source:HGNC Symbol;Acc:HGNC:11786] |
| Ensembl ID | ENSG00000186340 |
| Bio databases IDs | |
| Aliases | thrombospondin 2 |
| Synonyms | EDSCLL3, THROMBOSPONDIN 2, TSP-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THBS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- lectin-like domain
- LamG
- globular domain
- oligomerization domain
- calcium binding loop
- protein binding
- EGF-like domain
- thrombospondin type 3 repeat
- Thrombospondin C-terminal region
- von Willebrand factor type C domain
- thrombospondin properdin-like repeat
- EGF domain
- Spondin-like TSP1 domain
- heparin binding
Pathways
Biological processes and signaling networks where the THBS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- idiopathic pulmonary fibrosis
- liver cancer
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- fibrosis
- epithelial cancer
- intimal hyperplasia
- kyphosis
role in cell
- activation in
- expression in
- cell death
- cell viability
- apoptosis
- signaling in
- proliferation
- quantity
- migration
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cell periphery
- alpha granules
- extracellular matrix
- plasma
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THBS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- cell adhesion
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule
- basement membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heparin binding
- extracellular matrix structural constituent