P2RY4 Gene Summary [Human]
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | P2RY4 |
| Official Name | pyrimidinergic receptor P2Y4 [Source:HGNC Symbol;Acc:HGNC:8542] |
| Ensembl ID | ENSG00000186912 |
| Bio databases IDs | |
| Aliases | pyrimidinergic receptor P2Y4 |
| Synonyms | NRU, P2P, P2Y4, P2Y4R, pyrimidinergic receptor P2Y4, pyrimidinergic receptor P2Y, G-protein coupled, 4, UNR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human P2RY4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- UTP-activated nucleotide receptor
- ATP binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the P2RY4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- cellular infiltration by
- exocytosis
- shedding in
- response by
- elevation in
- calcium response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- apical membrane
- presynaptic membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human P2RY4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- regulation of synaptic vesicle exocytosis
- transepithelial chloride transport
- phospholipase C-activating G-protein coupled receptor signaling pathway
- cellular response to ATP
- cellular response to prostaglandin E stimulus
- G-protein coupled purinergic nucleotide receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- UTP-activated nucleotide receptor activity
- ATP binding
- protein binding
- G-protein coupled purinergic nucleotide receptor activity