H2AP Gene Summary [Human]
This gene encodes a protein shown to interact with huntingtin, which contains an expanded polyglutamine tract in individuals with Huntington's disease (PMID: 9700202). [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | H2AP |
| Official Name | H2A.P histone [Source:HGNC Symbol;Acc:HGNC:18417] |
| Ensembl ID | ENSG00000187516 |
| Bio databases IDs | |
| Aliases | H2A.P histone |
| Synonyms | 1700054O13Rik, CXorf27, H2al3, H2A.P histone, HIP17, HYPM, RGD1563155 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human H2AP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human H2AP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- nucleosomal DNA binding