ADH1A Gene Summary [Human]
This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | ADH1A |
| Official Name | alcohol dehydrogenase 1A (class I), alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:249] |
| Ensembl ID | ENSG00000187758 |
| Bio databases IDs | |
| Aliases | alcohol dehydrogenase 1A (class I), alpha polypeptide |
| Synonyms | ADH1, ADH1A1, ADH1 alpha, ADH1 α, alcohol dehydrogenase 1A (class I), alpha polypeptide, alcohol dehydrogenase 1A (class I), α polypeptide |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADH1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alcohol dehydrogenase
- MDR
- Zinc-binding dehydrogenase
- Alcohol dehydrogenase GroES-like domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- hepatocellular carcinoma
- uterine serous papillary cancer
- methanol poisoning
- preeclampsia
- organismal death
- Ullrich congenital muscular dystrophy
- soft tissue sarcoma cancer
regulates
- alcohol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Plasma Membrane
- basal bodies
- cytosol
- nucleoplasm
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADH1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinol metabolic process
- retinoic acid metabolic process
- alcohol metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- retinol dehydrogenase activity
- protein binding
- alcohol dehydrogenase (NAD) activity
- alcohol dehydrogenase activity, zinc-dependent