DBP Gene Summary [Human]
The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | DBP |
| Official Name | D-box binding PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:2697] |
| Ensembl ID | ENSG00000105516 |
| Bio databases IDs | |
| Aliases | D-box binding PAR bZIP transcription factor |
| Synonyms | Albumin d-box binding, Albumin gene d-box binding, DABP, D-box binding PAR bZIP transcription factor, D site albumin promoter binding, D site albumin promoter binding protein, taxREB302 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- PAR domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the DBP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- preeclampsia
- hypothyroidism
- epilepsy
- Huntington disease
- polycystic kidney disease
- endometriosis
role in cell
- expression in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- endosomes
- lysosome
- apical membrane
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rhythmic process
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity