COMMD6 Gene Summary [Human]
COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | COMMD6 |
| Official Name | COMM domain containing 6 [Source:HGNC Symbol;Acc:HGNC:24015] |
| Ensembl ID | ENSG00000188243 |
| Bio databases IDs | |
| Aliases | COMM domain containing 6 |
| Synonyms | 1110059J08Rik, 1700063H17RIK, Acrg, COMM domain containing 6, RGD1560745 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COMMD6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NF-kappaB binding
- COMM domain
- protein binding
- Commd
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COMMD6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- protein binding