COMMD8 Gene Summary [Human]
The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | COMMD8 |
| Official Name | COMM domain containing 8 [Source:HGNC Symbol;Acc:HGNC:26036] |
| Ensembl ID | ENSG00000169019 |
| Bio databases IDs | |
| Aliases | COMM domain containing 8 |
| Synonyms | COMM domain containing 8, D5Buc26e |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COMMD8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- COMM domain
- protein binding
- Commd
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COMMD8 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding