HUS1B Gene Summary [Human]
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HUS1B |
| Official Name | HUS1 checkpoint clamp component B [Source:HGNC Symbol;Acc:HGNC:16485] |
| Ensembl ID | ENSG00000188996 |
| Bio databases IDs | |
| Aliases | HUS1 checkpoint clamp component B |
| Synonyms | HUS1 checkpoint clamp component B, LOC683826 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HUS1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hus1-like protein
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HUS1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- double-strand break repair via homologous recombination
- telomere maintenance
- nucleotide-excision repair
- intra-S DNA damage checkpoint
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- nucleolus
- checkpoint clamp complex