Hus1b Gene Summary [Mouse]
Predicted to be involved in DNA integrity checkpoint signaling and DNA metabolic process. Predicted to be located in nucleolus. Predicted to be part of checkpoint clamp complex. Predicted to be active in site of double-strand break. Orthologous to human HUS1B (HUS1 checkpoint clamp component B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hus1b |
| Official Name | HUS1 checkpoint clamp component B [Source:MGI Symbol;Acc:MGI:2671003] |
| Ensembl ID | ENSMUSG00000076430 |
| Bio databases IDs | |
| Aliases | HUS1 checkpoint clamp component B |
| Synonyms | HUS1 checkpoint clamp component B, LOC683826 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hus1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hus1-like protein
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hus1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- double-strand break repair via homologous recombination
- telomere maintenance
- nucleotide-excision repair
- intra-S DNA damage checkpoint
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- nucleolus
- checkpoint clamp complex