RAD1 Gene Summary [Human]
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | RAD1 |
| Official Name | RAD1 checkpoint DNA exonuclease [Source:HGNC Symbol;Acc:HGNC:9806] |
| Ensembl ID | ENSG00000113456 |
| Bio databases IDs | |
| Aliases | RAD1 checkpoint DNA exonuclease, exonuclease homolog RAD1, checkpoint control protein HRAD1, cell cycle checkpoint protein Hrad1, Rad1-like DNA damage checkpoint, DNA repair exonuclease REC1, RAD1 checkpoint clamp component |
| Synonyms | HRAD1, mRAD1, RAD1 checkpoint DNA exonuclease, REC1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta_clamp
- damaged DNA binding
- enzyme
- protein binding
- Repair protein Rad1/Rec1/Rad17
Pathways
Biological processes and signaling networks where the RAD1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- brain cancer
role in cell
- cell viability
- accumulation in
- DNA damage response
- Gap 0-Gap 1 phase
- response by
- cohesion in
- cohesion
- accumulation
- checkpoint control
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nuclear foci
- chromosome
- nucleoplasm
- synaptonemal complexes
- chromosomal cores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic recombination checkpoint
- DNA repair
- DNA damage checkpoint
- cellular response to ionizing radiation
- response to DNA damage stimulus
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- chromosome
- nucleoplasm
- checkpoint clamp complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- damaged DNA binding