SYCP2 Gene Summary [Human]
The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SYCP2 |
| Official Name | synaptonemal complex protein 2 [Source:HGNC Symbol;Acc:HGNC:11490] |
| Ensembl ID | ENSG00000196074 |
| Bio databases IDs | |
| Aliases | synaptonemal complex protein 2 |
| Synonyms | 3830402K23Rik, 4930518F03RIK, SCP-2, SPGF1, synaptonemal complex protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYCP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex 2 armadillo-repeat-like domain
- coiled-coil domain
- protein binding
- Synaptonemal complex 2 Spt16M-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- spermatogenic failure 1
- diabetic nephropathy
- azoospermia
regulates
- Cohesin
- Axial element
role in cell
- formation
- apoptosis
- meiosis
- G1 phase
- necroptosis
- synapsis
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYCP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male genitalia morphogenesis
- germ cell programmed cell death
- female meiosis
- male meiosis
- synaptonemal complex assembly
- fertilization
- negative regulation of developmental process
- cell division
- negative regulation of apoptotic process
- apoptotic process
- G1 phase of mitotic cell cycle
- negative regulation of reproductive process
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome, centromeric region
- lateral element
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- DNA binding