STRA8 Gene Summary [Human]

This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]

Details

Type
Protein Coding
Official Symbol
STRA8
Official Name
stimulated by retinoic acid 8 [Source:HGNC Symbol;Acc:HGNC:30653]
Ensembl ID
ENSG00000146857
Bio databases IDs NCBI: 346673 Ensembl: ENSG00000146857
Aliases stimulated by retinoic acid 8
Synonyms LOC346673, RGD1562852, stimulated by retinoic acid 8, stimulated by retinoic acid gene 8
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STRA8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • basic Helix Loop Helix (bHLH) domain superfamily
  • protein binding

Pathways

Biological processes and signaling networks where the STRA8 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • azoospermia
regulated by
regulates
role in cell
  • expression in
  • meiosis
  • replication in
  • response by
  • premeiotic phase
  • lack
  • replication
  • cell division

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human STRA8 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • meiotic cell cycle
  • cellular response to retinoic acid
  • oogenesis
  • DNA replication
  • spermatogenesis
  • activation of meiosis
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • protein dimerization activity

Gene-Specific Assays for Results You Can Trust

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