Sycp2 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Acts upstream of or within several processes, including male genitalia morphogenesis; meiotic nuclear division; and negative regulation of apoptotic process. Located in lateral element. Is expressed in meiotic germ cell of ovary; oocyte; primary oocyte; and spermatocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 1. Orthologous to human SYCP2 (synaptonemal complex protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sycp2 |
| Official Name | synaptonemal complex protein 2 [Source:MGI Symbol;Acc:MGI:1933281] |
| Ensembl ID | ENSMUSG00000060445 |
| Bio databases IDs | |
| Aliases | synaptonemal complex protein 2 |
| Synonyms | 3830402K23Rik, 4930518F03RIK, SCP-2, SPGF1, synaptonemal complex protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sycp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex 2 armadillo-repeat-like domain
- coiled-coil domain
- protein binding
- Synaptonemal complex 2 Spt16M-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- spermatogenic failure 1
- diabetic nephropathy
- azoospermia
regulates
- Cohesin
- Axial element
role in cell
- formation
- apoptosis
- meiosis
- G1 phase
- necroptosis
- synapsis
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sycp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male genitalia morphogenesis
- germ cell programmed cell death
- female meiosis
- male meiosis
- synaptonemal complex assembly
- fertilization
- negative regulation of developmental process
- cell division
- negative regulation of apoptotic process
- apoptotic process
- G1 phase of mitotic cell cycle
- negative regulation of reproductive process
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome, centromeric region
- lateral element
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- DNA binding