SLC2A5 Gene Summary [Human]
The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
Details
| Type | Protein Coding |
| Official Symbol | SLC2A5 |
| Official Name | solute carrier family 2 member 5 [Source:HGNC Symbol;Acc:HGNC:11010] |
| Ensembl ID | ENSG00000142583 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 member 5 |
| Synonyms | GLUT-5, Slc5a, solute carrier family 2 (facilitated glucose transporter), member 5, solute carrier family 2 member 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC2A5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- monosaccharide binding
- Sugar (and other) transporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- phosphate:H+ symporter
- protein binding
- fructose transporter
- transporter
Pathways
Biological processes and signaling networks where the SLC2A5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypotension
- metastasis
- diabetic nephropathy
- colorectal cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- COVID-19
- Alzheimer disease
- organismal death
role in cell
- expression in
- phosphorylation in
- proliferation
- morphology
- quantity
- migration
- production
- invasion by
- differentiation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- specific granule membrane
- cytosol
- apical membrane
- basolateral membrane
- sarcolemma
- brush border
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC2A5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- response to fructose stimulus
- cellular response to fructose stimulus
- regulation of systemic arterial blood pressure mediated by a chemical signal
- fructose transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- sarcolemma
- apical plasma membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- fructose binding
- protein binding
- fructose transmembrane transporter activity
- glucose transmembrane transporter activity