SPOCK3 Gene Summary [Human]
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | SPOCK3 |
| Official Name | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 [Source:HGNC Symbol;Acc:HGNC:13565] |
| Ensembl ID | ENSG00000196104 |
| Bio databases IDs | |
| Aliases | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 |
| Synonyms | 2900045C01Rik, HSAJ1454, mKIAA4039, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3, TES-3, TICN3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPOCK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- EFh_SPARC_EC
- TY
- signal peptide
- EFh
- Secreted protein acidic and rich in cysteine Ca binding region
- metalloendopeptidase inhibitor
- KAZAL_FS
- unique protein domain
- glycosaminoglycan binding
- follistatin (FS) domain
- calcium binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPOCK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell motility
- negative regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- calcium ion binding
- metalloendopeptidase inhibitor activity