GPC4 Gene Summary [Human]
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GPC4 |
| Official Name | glypican 4 [Source:HGNC Symbol;Acc:HGNC:4452] |
| Ensembl ID | ENSG00000076716 |
| Bio databases IDs | |
| Aliases | glypican 4, glypican proteoglycan 4 |
| Synonyms | 9530073D23RIK, Glypican-4, K-glypican, KPTS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glypican
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Simpson-Golabi-Behmel syndrome type 1
- nasodigitoacoustic syndrome
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- hemimegalencephaly
- rheumatoid arthritis
- anemia
- craniosynostosis
- psoriatic arthritis
role in cell
- differentiation
- adhesion
- disruption
- assembly
- disruption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- glutaminergic synapse
- cell surface
- cellular membrane
- Nucleus
- plasma membrane extracellular face
- presynaptic membrane
- lysosomal compartment
- synaptosomes
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Wnt receptor signaling pathway
- cell migration
- regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- external side of plasma membrane
- lysosomal lumen
- synapse
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding