Spock3 Gene Summary [Rat]
Predicted to enable several functions, including calcium ion binding activity; collagen binding activity; and metalloendopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spock3 |
| Official Name | SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 [Source:RGD Symbol;Acc:1305672] |
| Ensembl ID | ENSRNOG00000029903 |
| Bio databases IDs | |
| Aliases | SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 |
| Synonyms | 2900045C01Rik, HSAJ1454, mKIAA4039, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3, TES-3, TICN3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spock3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- EFh_SPARC_EC
- TY
- signal peptide
- EFh
- Secreted protein acidic and rich in cysteine Ca binding region
- metalloendopeptidase inhibitor
- KAZAL_FS
- unique protein domain
- glycosaminoglycan binding
- follistatin (FS) domain
- calcium binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- schizophrenia
- conotruncal heart malformations
- colorectal cancer
- systemic lupus erythematosus
- glioblastoma
- glioblastoma cancer
regulates
- MMP2
- endopeptidase
role in cell
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spock3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell motility
- negative regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- calcium ion binding
- metalloendopeptidase inhibitor activity