SDC4
SDC4 Gene Summary
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SDC4 |
| Official Name | syndecan 4 [Source:HGNC Symbol;Acc:HGNC:10661] |
| Ensembl ID | ENSG00000124145 |
| Bio databases IDs | |
| Aliases | syndecan 4, syndecan proteoglycan 4 |
| Synonyms | RATRYUDOCA,RYUDOCA,RYUDOCAN,S4,SYND4,syndecan-4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol 4,5-biphosphate binding domain
- extracellular domain
- EFYA motif
- signaling receptor activity
- ectodomain
- protein kinase C binding
- protein binding
- identical protein binding
- fibronectin binding
- putative band 4.1 homologues' binding motif
- Syndecan domain
- cytoplasmic domain
- transmembrane domain
- C2 region of the Syndecan family
- cytosolic tail domain
- PDZ binding motif
Pathways
Biological processes and signaling networks where the SDC4 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SDC2
- SDC4
- MDK
- CDK9
- CAVIN1
- RCOR1
- phosphatidylinositol 4-phosphate
- SQSTM1
- LAMA3
- phosphatidylinositol 4,5-bisphosphate
disease
- Huntington disease
- rheumatoid arthritis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- organismal death
- degenerative disc disease
- surgically induced osteoarthritis
- psoriatic arthritis
- knee osteoarthritis
regulated by
- lipopolysaccharide
- POR
- NFkB (complex)
- STAT3
- IL1B
- EGF
- torkinib
- TGFB1
- tetradecanoylphorbol acetate
- beta-estradiol
regulates
- IL1B
- FN1
- JNK
- TNC
- AKT
- p38 MAPK
- proteoglycan
- RELA
- ATF2
- PKC
role in cell
- expression in
- migration
- molecular cleavage in
- apoptosis
- accumulation in
- activation in
- proliferation
- invasion
- growth
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- perinodal process
- Cytoplasm
- cell-associated matrix
- cell surface
- cell borders
- perinuclear region
- cellular tail
- cellular membrane
- focal adhesions
- Golgi Apparatus
- costameres
- cytosol
- lysosomal compartment
- internodes
- gap junctions
- cell-matrix adherens junctions
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SDC4 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- inner ear receptor stereocilium organization
- wound healing
- positive regulation of focal adhesion assembly
- neural tube closure
- ureteric bud development
- positive regulation of stress fiber assembly
- negative regulation of T cell proliferation
- cell migration
- regulation of fibroblast migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- costamere
- lysosomal lumen
- Golgi lumen
- plasma membrane
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase C binding
- thrombospondin receptor activity
- identical protein binding
- protein binding
- fibronectin binding