IPO4 Gene Summary [Human]
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in DNA replication-dependent chromatin assembly; DNA replication-independent chromatin assembly; and protein import into nucleus. Located in chromatin. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IPO4 |
| Official Name | importin 4 [Source:HGNC Symbol;Acc:HGNC:19426] |
| Ensembl ID | ENSG00000196497 |
| Bio databases IDs | |
| Aliases | importin 4 |
| Synonyms | 8430408O15Rik, Imp4, Imp4a, IMP4B, importin 4, Importin 4b, RanBP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IPO4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- HEAT-like repeat
- protein binding
- Importin-beta N-terminal domain
- nuclear localization sequence binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- focal segmental glomerulosclerosis
- cellulitis
- abscess
role in cell
- cell viability
- apoptosis
- biogenesis
- aggregation in
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IPO4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
- protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- macromolecular complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- nuclear localization sequence binding