Vkorc1l1 Gene Summary [Mouse]
Enables vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in vitamin K metabolic process. Is active in endoplasmic reticulum membrane. Is expressed in liver. Orthologous to human VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vkorc1l1 |
| Official Name | vitamin K epoxide reductase complex, subunit 1-like 1 [Source:MGI Symbol;Acc:MGI:1916818] |
| Ensembl ID | ENSMUSG00000066735 |
| Bio databases IDs | |
| Aliases | vitamin K epoxide reductase complex, subunit 1-like 1 |
| Synonyms | 2310024K08RIK, LOC103693015, vitamin K epoxide reductase complex subunit 1 like 1, vitamin K epoxide reductase complex, subunit 1-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vkorc1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- vitamin-K-epoxide reductase (warfarin-sensitive)
- enzyme
- protein binding
- Vitamin K epoxide reductase (VKOR) family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma formation
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- EGFR expression positive non-squamous non-small cell lung cancer
regulates
- vitamin K
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vkorc1l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vitamin K metabolic process
- peptidyl-glutamic acid carboxylation
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- quinone binding
- vitamin-K-epoxide reductase (warfarin-sensitive) activity