STRN3 Gene Summary [Human]
Enables armadillo repeat domain binding activity; protein phosphatase 2A binding activity; and small GTPase binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | STRN3 |
| Official Name | striatin 3 [Source:HGNC Symbol;Acc:HGNC:15720] |
| Ensembl ID | ENSG00000196792 |
| Bio databases IDs | |
| Aliases | striatin 3, cell cycle S/G2 nuclear autoantigen, protein phosphatase 2 regulatory subunit B'''beta |
| Synonyms | G2sna, GS2NA, PPP2R6B, SG2NA, S/G2NA, striatin 3, striatin, calmodulin binding protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STRN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein kinase binding
- protein phosphatase binding
- protein binding activity, bridging
- WD domain, G-beta repeat
- enzyme binding
- coiled-coil domain
- WD40
- protein domain specific binding
- protein binding
- Striatin family
- binding protein
- WD40 repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- breast cancer
- Huntington disease
- papillary thyroid carcinoma
- papillary thyroid cancer
- colorectal cancer
- septic shock
- glioma formation
- asthma
- plasma cell myeloma
regulates
- STK26
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- proliferation
- polarization in
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- postsynaptic region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STRN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- negative regulation of transcription, DNA-dependent
- response to estradiol stimulus
- negative regulation of intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- Golgi apparatus
- macromolecular complex
- neuronal cell body
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- armadillo repeat domain binding
- small GTPase binding
- protein binding, bridging
- protein phosphatase 2A binding